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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Pyrazolo[1,5-a]pyridine

Pyrazolo[1,5-a]pyridine

Pyrazolo[1,5-a]pyridine Structure
  • ₹0
  • Product name: Pyrazolo[1,5-a]pyridine
  • CAS: 274-56-6
  • MF: C7H6N2
  • MW: 118.14
  • EINECS:
  • MDL Number:MFCD08752622
  • Synonyms:PYRAZOLO[1,5-A]PYRIDINE;3-Azaindoline;1H-Pyrazolo[1,5-a]pyridine;6,7a-dimethyl-2,3,5,6-tetrahydrooxazolo[2,3-b]oxazole;Pyrazolo[1,5-a]pyridine,97%
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :37-39℃/0.2mm
Density :1.14±0.1 g/cm3(Predicted)
refractive index :1.6075
storage temp. :Sealed in dry,Room Temperature
pka :2.83±0.30(Predicted)
form :Liquid
color :Colorless to red or brown
InChI :InChI=1S/C7H6N2/c1-2-6-9-7(3-1)4-5-8-9/h1-6H
InChIKey :DVUBDHRTVYLIPA-UHFFFAOYSA-N
SMILES :C12=CC=NN1C=CC=C2

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Pyrazolo[1,5-a]pyridines, a class of fused heteroaromatic bicyclic compounds, have been investigated for their pharmacological and biological activities. They are used as dopamine D2/D3/D4 antagonists, anti-herpetic agents, p38 kinase inhibitors, PI3 kinase inhibitors, antitubercular agents, EP1 receptor antagonists, 5HT3-antagonists, melatonin receptor (MT1/MT2) ligands, Mcl-1Bcl-xL dual inhibitors, and corticotropin-releasing factor 1 antagonists. Pyrazolo[1,5-a]pyridine has been used as a fluorophore in the research of Zhang et al. and exhibited high quantum yield (0.64, pH 2.4), high selectivity and sensitivity, and extremely short response time[1].

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